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Early data show that if a patient has been highly successful with GLP-1s, they are likely to be highly successful with weight-loss surgery because they work through many of the same mechanisms

Leaving it on the counter, even for a few hours, accelerates degradation

Kumar offers both caution and some insight

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The results, which were published in the Lancet on Thursday, are very encouraging for the safety and efficacy of orforglipron in people with type 2 diabetes, says Daniel Drucker, an endocrinologist at the University of Toronto, adding that he is awaiting further clinical trial results of the drug in people with obesity

It is designed for patients who are prepared to begin at higher therapeutic levels and may achieve visible results more quickly