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3.1.2 ARPE-19 cell model The ARPE-19 cell line is derived from adult retinal pigment epithelial (RPE) explants, and ARPE-19 cells can be extensively expanded, providing a relatively stable source of retinal epithelial cells for functional and genetic research (Golconda et al., 2023)

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Acknowledgements We thank OPEN Health Communications for their editorial and graphics support, as well as coordination during the manuscript development, which was funded by Novo Nordisk A/S

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Nicotine is considered to be a potent nootropic that is naturally occurring in many plants, especially tobacco