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estimated treatment difference 2.4 kg).26 Tirzepatide use was evaluated in 579 participants with BMI 30, or BMI 27 with at least 1 weight-related complication, who were able to achieve at least 5% weight loss with a 12-week intensive lifestyle intervention.27 After an average 6.9% change in body weight with the lifestyle intervention, there was a further mean weight change of 18.4% at 72 weeks with tirzepatide at maximum tolerated dose (10 mg or 15 mg weekly), compared with a weight gain of 2.5% with placebo (estimated treatment difference 20.8%, 95% CI 23.2 to 18.5).27 We identified no dedicated RCT evaluating naltrexonebupropion for prevention of weight regain or long-term maintenance in people with obesity