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No significant differences were observed in age, sex, or baseline comorbidities

Xia M, Li C, Zhang Y, et al

They engineered molecular modifications that extended the half-life to seven days, enabling truly once-weekly dosing

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A subsequent study supported this finding by demonstrating that the energy expenditure of mice treated with the conjugate resembles that of the heavier control animals undergoing monotherapy treatment with GLP-1 and MK-801 (Extended Data Fig

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