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This toxic metabolite of VPA belongs to a class of organic compounds known as methyl-branched fatty acids [97]

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The shared developmental origin of MTNs and certain cerebellar neurons, under the influence of potent signaling molecules such as Wnt1 and Fgf8 secreted from the isthmic organizer, suggests the presence of a common developmental program underlying neuronal populations involved in sensorimotor integration

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Afterward, you typically begin increasing the dose until reaching a therapeutic level, or the point at which the medication produces the maximal desired effect