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These effects are thought to occur through GLP-1s influence on both peripheral (vagal) and central pathways, including the hindbrain, hypothalamus, and brain regions involved in motivation and reward, which help regulate appetite and metabolism [8, 14, 18]

The team then showed that mice whose gut microbiota had been depleted using broad-spectrum antibiotics did not experience liraglutides antidepressant effects, pointing to a key role for the microorganisms in the gut

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A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes