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Given these limitations and the absence of convincing data to support restriction, the INASL guidelines advise against limiting fruit intake in cirrhotic patients

The consequent block of autophagy triggers the further accumulation of cellular waste like damaged mitochondria and protein aggregates, which contributes to overall cellular damage and leads to neuronal cell death and neurodegeneration 53

Pharmacologically, KEAP1 activity can be inhibited by the compound bardoxolone (CDDO) 68

In conclusion, a therapeutic approach to IVD degeneration involving enhanced tissue repair by exogenous growth factors may be clinically important, but more research is needed to address the efficacy, duration of action, safety, and adverse effects of the growth factors administered in vivo

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