Tirzepatide also affected proteins involved in neurotransmission, such as solute carrier family 6 member 6 (SLC6A6), reticulon 3 (RTN3), proline-rich transmembrane protein 2 (PRRT2), alpha-aminoadipic semialdehyde synthase (AASS), and microtubule-associated protein 1A (MAP1A)
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Strategies such as the construction of chimeric capsids, peptide library screening, and chemical conjugation have been used to improve AAV vector specificity and transduction efficiency
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These findings are consistent with the NMDA-R hypofunction model
