Choosing Between Semaglutide and Tirzepatide for Microdosing From a pharmacology standpoint, semaglutide is a pure GLP-1 receptor agonist , while tirzepatide is a dual GIP/GLP-1 agonist that activates both GIP and GLP-1 receptors.[2,4] That dual mechanism likely contributes to tirzepatides strong weight-loss results at full doses compared with semaglutide in head-to-head and indirect comparisons.[2,7] In the context of microdosing: Some clinicians and patients feel that microdosing tirzepatide provides robust appetite control even at relatively low doses, though this is based largely on real-world experience rather than large trials
The real impact will depend on how rebate structures and formulary positioning adjust in response
Whatever the reason, you can still indulge too much even on a GLP-1, which means a stomach that already thinks it is full will feel even fuller, often leading to nausea
B (Methodol.) 57 , 289300 (1995)
Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, et al
And this has actually been the problem ever since to find the correct balance between the side effects and the effects of the peptide
