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It is involved in many aspects of metabolism including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds.
SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol
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Substituting these amino acids influenced both the catabolism [49, 52] and neonatal transcytosis [52] of mouse IgG1 fragments in wild-type (WT) mice in a manner that correlated with the binding affinity of the mutated Fc fragments towards mouse FcRn at pH 6.0 [51]
doi: 10.1136/bmjopen-2022-061476
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