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Lets say you start at 200 pounds and eat around 2,000 calories a day to lose roughly a pound a week

This contrasts with some concerns about GLP-1 receptor desensitization

In theory, this could counterbalance any insulin resistance from tesamorelin GH elevation

In clinical trials, the typical person lost about 15% of their total body weight while taking semaglutide, and about 12% more weight than people who didnt take the medication

Early animal experiments with hypothalamic lesions and post-mortem examinations in humans with morbid obesity led to a proposal of the dual center hypothesis, postulating that ventromedial nuclei (VMN) serve as the satiety center and the lateral hypothalamic area (LHA) - as the feeding or hunger center (4) that when stimulated results in hyperphagia and subsequently hypothalamic obesity (5, 6)

This leads to mild dehydration and a significant reduction in saliva production