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Consequently, Cl - efflux occurs upon GABAA receptor activation, leading to depolarization of the postsynaptic membrane and an excitatory effect of GABA

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Clemente SM, Martnez-Costa OH, Monsalve M, Samhan-Arias AK (2020) Targeting lipid peroxidation for cancer treatment

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At Week 26, treatment with a 2 mg dose of EGRIFTA (1 mg/vial formulation) resulted in a reduction from baseline in mean trunk fat of 1.0 kg in Study 1 and 0.8 kg in Study 2, respectively (compared with an increase of 0.4 kg in Study 1 and of 0.2 kg in Study 2, respectively, in patients receiving placebo)

Most protocols stack them together because pressing both receptors at once creates a larger GH pulse than either one alone