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The analysis revealed that the upregulated proteins in CHL were significantly enriched in serine-type endopeptidase activity ( p adjusted = 7.0E-11), heparin binding ( p adjusted = 1.3E-07), and complement binding ( p adjusted = 0.0009) (Supplementary Table S6

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The cerebral effect of ammonia in brain aging: Blood-brain barrier breakdown, mitochondrial dysfunction, and neuroinflammation