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Patients with neurological involvement require more intensive initial treatment with injections on alternate days until no further improvement occurs

in patients at increased risk of hypoglycemia consider reducing the dose of insulin at initiation of semaglutide, followed by careful titration

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On the other hand, extended sleep duration, often observed in atypical depression, may also alter circadian rhythm, which is important for metabolic health, reduce physical activity, and worsen insulin sensitivity, complicating glycemic control [51, 52]

Patients were also made aware of similar studies performed in the field of orthopedics