Ann Pharmacother (2020) 54(5):47885
Thus, the conjugate seemingly harnesses the dual pharmacological benefits of hypothalamic GLP-1 receptor agonism and NMDA receptor antagonism while mitigating adverse behavioural effects linked to the latter
The following is a brief introduction to its bioanalytical strategy with specific case studies
Sharing a 94% structural homology with native human GLP-1, Semaglutide is distinguished by three modifications: 1) amino-acid substitutions at position 8 (alanine to -aminoisobutyric acid or Aib) and position 34 (lysine to arginine), and acylation of the lysine in position 26 with a spacer consisting of two 8-amino-3,6-dioxaoctanoic acid (ADO) moieties, a glutamic acid moiety, and a C-18 fatty di-acid side chain (Lau et al., 2015)
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