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347,348,349 Similarly, MSU promotes the expression of other cytokines, such as interleukin-6 (IL-6), tumor necrosis factor- (TNF-), and interferon gamma (IFN-), and chemokines, such as monocyte chemotactic protein-1 (MCP-1)

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Zhang et al., 2023) and with a transformation from A2 (neuroprotective) astrocytes to A1 (neurotoxic) astrocytes, resulting in damage to the hippocampus and impaired spatial learning (She et al., 2022)