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large-scale randomised controlled trials specifically designed to assess cognitive outcomes are still ongoing Uncertainty about mechanisms : It remains unclear whether any cognitive effects result from direct brain effects, improved metabolic control, or other factors Population specificity : Most research has focused on individuals with type 2 diabetes
It was causing so much frustration and anxiety
It also carries an increased risk of a second cancer developing in the treated site
serious AEs were defined per ICH-GCP
When pyruvate is converted into acetyl coenzyme A, this step is irreversible and therefore carbohydrates can be converted into fats but not vice versa (106)
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