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AF was obtained from the AF Consortium with 60,620 cases and 970,216 controls [28]

CR, or the reduction of daily caloric intake without malnutrition (~20%), has been repeatedly associated with a decrease in cancer incidence in animal models since the very early 20th century (46), including in primates (47, 48)

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The capsule is a standard size

It promotes modest weight loss via cardiometabolic effects through various alterations in neuronal appetite center, liver glucose metabolism, muscle glucose utilization, and lactate production