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For this reason, a remarkable number of inhibitors for GSTs have been synthesized as well as GSH analogues with better specificities and reduced toxicities 69,87

Mechanistically, artemisinin and its derivatives directly target LONP1 in theca-interstitial cells, enhancing its interaction with cytochrome P450 family 11 subfamily A member 1 (CYP11A1) and promoting LONP1-catalyzed degradation of CYP11A1

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Biochem Biophys Res Commun 289:8084 Lushchak VI (2012) Glutathione homeostasis and functions: potential targets for medical interventions

Also, poly (GR) 80 interacts with mitochondrial ribosomal proteins, inducing mitochondrial dysfunction, in motor neurons differentiated from C9orf72 patient iPSCs, compared to controls (Lopez-Gonzalez et al., 2016)