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It is called non-specific because, after doctors do tests, they do not find a clear cause like a heart attack, lung problem, or acid reflux

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MECHANISM OF ACTION: A dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist activates both the GIP and GLP-1 receptors, and as a result it effectively regulates glucose levels, reduces appetite and promotes weight loss

However, the DPP/DPPOS 21-year follow-up did not find a statistically significant reduction in major cardiovascular events with metformin versus placebo, though favorable trends in risk factors were observed

These medications offer substantial weight reductionoften 15-20% of body weightraising important questions about their safety and efficacy specifically in patients with fatty liver disease