Traditional guidelines have emphasized metformin as initial treatment due to its proven safety, low cost, and cardiovascular benefits
Contact your GP or diabetes specialist nurse if you experience: Severe, unrelenting nausea or vomiting lasting more than 24-48 hours, particularly if preventing adequate fluid or medication intake Persistent diarrhoea with signs of dehydration (dark urine, dizziness, reduced urination, dry mouth) Severe abdominal pain , especially if constant, worsening, or accompanied by fever Blood in vomit or stools , which requires urgent assessment Signs of dehydration require prompt intervention, particularly in vulnerable patients such as older adults or those with kidney disease
Miller DR, Rosenberg L, Kaufman DW, Stolley P, Warshauer ME, Shapiro S
Wegovy (semaglutide) European Medicines Agency
Understanding the safety considerations can help with choosing the best option
The arm was stiff and sore to the point I said about it to another nurse
