The second trial, IMPACT 2, had a similar design, except that crossover to active therapy for the placebo arm took place at 24 weeks, although patients with active disease could enter an early escape at 16 weeks
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This is the broader theme in Metos companion piece: peptides and GLP-1s are not inherently competitors
The implant is a small titanium cylinder that houses a reservoir that contains a high-concentration formulation of the medicine
Retatrutide layered glucagon receptor agonism on top and reached approximately 24% in Phase 2 data
Another hypothesis has speculated the role of ghrelin, a gut hormone able to enhance gastric emptying, in the pathogenesis of rapid GET during the remission period
