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By comparing reconstructed 3D volumes of each cluster, the particle stacks representing distinct states were identified and subsequently subjected into the non-uniform consensus refinement and the receptor-focused refinement

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In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls

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Supports microvascular stability in preclinical models