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Therefore, vitamin B12 should only be injected by a health care professional who is prepared to provide first aid immediately

The 28-day rule is a safety standard based on the known efficacy of the preservative, and it should be strictly followed regardless of the waters appearance

For patients who have not previously been diagnosed with vitamin B12 deficiency or prescribed a vitamin B12 injection, the medicine can be offered if vitamin B12 deficiency is suspected based on signs, symptoms and/or risk factors, though confirmation of vitamin B12 deficiency by a reliable test kit should also be considered

Potential involvement of altered carnitine palmitoyltransferase-I activity

Relative contraindications (metformin use, proton pump inhibitors) require monitoring

doi:10.1016/j.ejphar.2019.172593 50