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COMPARATIVE EFFECTS OF GLUCAGON-LIKE PEPTIDE-1 AND GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE Both GLP-1 and GIP have profound effects on energy metabolism and body weight (Table 1)

However, a 2025 meta-analysis published in the Journal of the American Heart Association found that people who had been taking GLP-1 medications for 78 weeks or longer (roughly a year and a half) had a significantly higher risk of developing a DVT compared to non-users

cAMP increases the sensitivity of exocytosis to Ca 2+ primarily through protein kinase A in mouse pancreatic beta cells

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