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Combo versus conventional pharmacology NSAIDs (ibuprofen, diclofenac) reduce acute pain and inflammation but delay tissue repair by blocking the constructive inflammatory phase

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Boston, MA, USA: 1992

The underlying mechanism may be related to GSH metabolism (163), abnormal iron metabolism (164), lipid peroxidation (165) and mitochondrial dysfunction (166)

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GSH is a critical molecule in resisting oxidative stress with the enzyme glutathione reductase (GR) recycling oxidized glutathione back to the reduced form