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Li P, Wang Y, Luo J, Zeng Q, Wang M, Bai M, et al

Sirtuin 1 (SIRT1) negatively regulates GH-induced IGF-1 production in the liver by directly inhibiting signal transducer and activator of transcription 5 (STAT5) activation, which causes GH resistance under prolonged fasting, starvation, and malnutrition [6]

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Natural-looking and long-lasting results are evident after the therapy

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As demonstrated by MP0250 28 , the therapeutic protein's half-lives can be significantly extended by genetically fusing non-HSA-binding DARPins or other therapeutic proteins to albumin-binding DARPins