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Although systemic inflammation is known to modulate iron metabolism, such as interleukin-6 (IL-6) stimulating hepcidin synthesis and subsequently downregulating FPN1, this has been observed primarily in hepatic tissues (95)

Administration technique DSIP is typically administered subcutaneously, though other routes have been studied

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Gut microbiota: primary producers of trimethylamine Gut microbiota, particularly Firmicutes and Proteobacteria , are key mediators of TMA production through distinct enzymatic pathways (51, 52)