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Nat Med 29:710718 World Population Review (2022) Wu S, Yang Z, Liu S, Zhang Q, Zhang S, Zhu S (2025) Sugar-sweetened beverages, artificially sweetened beverages and sugar forms with long-term risk of irritable bowel syndrome: a large-scale prospective cohort study

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Expected outcomes based on trial data: Average weight loss of 24.2% at 48 weeks (phase 2) Average weight loss of 28.7% at 68 weeks (phase 3, TRIUMPH-4) 100% of participants achieved 5% or greater weight loss 93% achieved 10% or greater 83% achieved 15% or greater Moderate weight loss protocol (8mg target) For researchers who want significant weight loss but have a lower tolerance for side effects, stopping the escalation at 8mg is a validated approach

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A COA that reports results without identifying who performed the testing lacks the independence that makes COA verification meaningful