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Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism

PMID: 24199705

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Sikiric et al., 2018) as well as counteracting harmful escape from the initial healing effect (i.e., angiogenesis)

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Giving NAC to a small group of early psychosis patients did not make their negative symptoms worse, but it did improve their cognition and raise GSH levels in the medial prefrontal cortex of their brains (185)