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These results implicate astrocytic enzyme dysregulation as a critical driver of GABA imbalance, further supporting the role of astrocytes in PTSD pathophysiology

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10,278 Genetic suppression of the IKK/NF-B pathway, achieved through the deletion of one p65 allele, or pharmacological intervention via IKK inhibitors, such as 8K-NBD, has been shown to delay the onset and mitigate the severity of aging symptoms and age-related pathologies in the nervous system of murine models 10,279