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The main outcome variable to be monitored in both treatment arms is the normalisation of the serum vitamin B12 concentration at weeks 8, 26 and 52

Biochimie 94(11):22642279 Marks PA, Richon VM, Rifkind RA (2000) Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

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This dual dependency on CYP3A4 and P-gp creates a well-defined vulnerability