PD is caused by the disruption of dopaminergic neurotransmission in the basal ganglia, which causes a reduction in the numbers of dopaminergic neurons in the substantia nigra and formation of cytoplasmic inclusions called Lewy bodies [1]
Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible
Brian Lee, an associate professor of medicine at Keck School of Medicine of USC in Los Angeles, voted no, arguing that the public could view the votes and FDA sign-off as endorsements of the products and that some of the compounds may be no better than a placebo
Further examination revealed that Cyperus scariosus R.Br
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