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These effects were generally mild to moderate in severity and tended to diminish over time as the body adapted

Glossary 2-AG 2-arachidonoylglycerol 5-HT1A 5-hydroxytryptamine receptor 1A (serotonin receptor 1A) AEA anandamide BBB bloodbrain barrier BDNF brain-derived neurotrophic factor BrdU bromodeoxyuridine CB1R cannabinoid receptor 1 CB2R cannabinoid receptor 2 CBD cannabidiol CBP cannabis-based products CNS central nervous system COX-2 cyclooxygenase-2 DCX doublecortin ECS endocannabinoid system FAAH fatty acid amide hydrolase GFAP glial fibrillary acidic protein GSH/GSSG reduced glutathione/oxidized glutathione ratio GSK-3 glycogen synthase kinase 3 beta IFG inflammaging IGF-2 insulin-like growth factor 2 IL-1 interleukin-1 IL-6 interleukin-6 LPS lipopolysaccharide MDMA 3,4-methylenedioxymethamphetamine MWT Morris water maze (test) NF-B nuclear factor kappa-light-chain-enhancer of activated B cells NO nitric oxide NOR novel object recognition (test) Ph

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Supplement Industry: Commonly found in dietary supplements, it is marketed for its potential benefits in boosting energy levels and improving mental clarity

The ACC notes that clinicians should pay attention to gastrointestinal side effects, drug interactions, nutrition, and the patients overall cardiovascular situation when using GLP 1 therapies in practice

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