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The cellular damage inflicted by ROSs is influenced not only by their intracellular concentration but also by the balance between ROSs and endogenous antioxidant mechanisms

201,203,205 In general, pathways involved in the activation of mast cells are potential targets to design effective drugs to control allergic asthma attacks

Thus, caspase-8mediated apoptosis may serve as a safeguard against necroptotic cell death, which is more inflammatory [73, 74]

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