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Clinical trials represent the most resource-intensive and failure-prone phase of drug R&Dand are even more complex in the context of rare diseases (Table 1)

6.5.1 Technological innovations in exposure assessment 6.5.1.1 Advanced analytical technologies Single-cell omics approaches enable detection of EED-induced epigenetic changes in individual sperm cells, providing unprecedented precision in exposure assessment (145)

It neutralises various oxidants like toxins, superoxide, lipid peroxide and carbon radicals

Even short exposures to heat can degrade quality

Secondary outcomes Any adverse event during the course of the study was monitored and reported to the study staff at week 6 (visit 5) or week 12 (visit 8) in the clinic or directly to principle investigator throughout the study

Cell 27 , 149162 (2007)