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Safety Profile and Tolerability Concerns Gastrointestinal Adverse Effects While GLP-1RAs are effective in managing obesity, their use is associated with gastrointestinal side effects and rare but serious adverse events [42] [43] [44]

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With the US in the midst of an opioid epidemic in which it is estimated that one person dies of an overdose every five minutes, Penn State College of Medicine is among the first to investigate the potential of GLP-1 drugs for the treatment of addiction