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doi:10.1007/s10549-025-07678-7 Lus C, Dias J, Firmino-Machado J, et al

Investigacin sobre el envejecimiento saludable: Un artculo publicado en la revista *Science* en 2023 describa los efectos sobre la esperanza de vida y la esperanza de vida saludable en modelos animales, pero las afirmaciones sobre los efectos antienvejecimiento en humanos son prematuras sin ensayos clnicos ms slidos que evalen los resultados en personas

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These observations further highlight the potent synergistic impact of leptin reduction on conventional interventions leading to weight loss