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Although a great effort has been made to develop organ-specific nucleic acid delivery systems, the design of active-targeted carriers with high quality, good clinical translation, and large-scale manufacturing capacity is still challenging

Histomorphometric analysis was performed as previously described 7 using H&E-stained sections for the quantification of growth plate area and Hoechst-stained sections for the quantification of chondrocyte cell density (two sections per mouse

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The planting pit dimensions should be 1 meter in length, width, and depth