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They are a commonly used model for studying the intestinal epithelial barrier

Ookubo et al

261265 Therefore, by inducing pro-inflammatory adhesion molecules and chemokines, hypoxia causes the accumulation of macrophages in the kidney that produce profibrotic cytokines such as transforming growth factor and activate renal fibrobalsts

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L., Giubilato, S., Cornara, S., Nesti, M., Rao, C

Daily 2.5mg or 5mg builds steady tissue levels after about 5 days, removing the need to time each encounter