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Despite the bodys robust antioxidant defenses, the increasing burden of oxidative stress due to factors like environmental pollutants, unhealthy diets, and chronic diseases often overwhelms these defenses

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It is currently in clinical trials for the treatment of inflammatory bowel disease

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By enhancing the secretion of insulin, delaying gastric emptying, and suppressing appetite, semaglutide effectively aids in blood sugar control and promotes weight loss

In addition, the membrane susceptibility to ferroptotic damage is modulated by its lipidomic composition, with phospholipids enriched in PUFAs, particularly arachidonic acid (AA) and adrenic acid (AdA), being especially prone to peroxidation, thereby rendering membrane vulnerability to ferroptosis (24)