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Found in vegetable oils, nuts, seeds, and fatty fish, LCFAs are essential for brain fuel and energy but must be metabolized more slowly than MCFAs, making them a more prolonged energy source

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10.1016/j.theriogenology.2010.12.006 78

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9 This is the first human study to demonstrate that a single dose of NR can cross into the brain and directly raise cerebral NAD+ levels, providing evidence that NR boosts NAD+ where it matters mostat the cellular level in the brain

Natelson and others, Shungu, from 2009-2017 demonstrated in a series of five studies that lactate was increased and glutathione decreased in the brains (ventricles) of people with ME/CFS