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In infected cells, all three proteins are initially inserted into the endoplasmic reticulum (ER) and are then trafficked to the ER-Golgi intermediate compartment (ERGIC) and the Golgi where they are glycosylated, and in the case of S also cleaved, by Golgi enzymes 7,8

Two transcriptomic analyses of ivermectin-resistant ticks compared to susceptible ticks found that cytochrome P450 had an important role in ivermectin resistance in ticks (Ruiz-May et al

BPC-157 upregulates VEGFR2 expression and promotes receptor internalization, triggering downstream phosphorylation of Akt at specific sites (Ser473 and Thr308)

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References Maquart FX, Simon A, Pasco S, Monboisse JC