Severity of symptoms appears to correlate with time spent in toxic environments, such as old office or apartment buildings
Customizable dosing to meet individual patient needs.
First-pass metabolism: Anything that survives the gut must pass through the liver, where it may be further processed before reaching the rest of the body
Subcutaneous B12 administration, although promising in select cases such as congenital cobalamin disorders, lacks comprehensive comparative studies against IM and oral routes
Gut barrier damage and endotoxemia: mechanisms and effects Under hyperthermic conditions, superficial blood vessels dilate to dissipate heat, leading to reduced blood flow to visceral organs (especially the intestinal mucosa) in a murine heat stress model, which in turn causes damage and apoptosis of intestinal epithelial cells, increased intestinal epithelial permeability, and impaired intestinal mucosal barrier [17]
PMID 10796740