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While mutagenesis studies clearly reveal that these residues within TM2 and ECL2 are important for both GLP-1 and oxyntomodulin function, alanine mutations in these regions generally had a larger impact on GLP-1 (Figs

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With the encouraging results of cancer immunotherapy in recent years, more investigation into the impact of glutamine metabolism on immune cell function in the cancer microenvironment could lead to the discovery of new targets and therapeutic approaches