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Due to the high expression profile of GLP-1R in pancreatic -cells, GLP-1 analogs (such as exendin-4) have been modified by different methods (to prolong half-life, maintain receptor binding affinity and reduce renal drug accumulation) for theranostic purposes and serve as excellent templates for future cardiovascular drug development[178-184]
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Tramadol was added to the list of prohibited substances in 2024
The development of oral semaglutide, an oral GLP-1 analog, for the treatment of type 2 diabetes
Retatrutide targets three hormone receptorsGLP-1, GIP, and glucagonwhile semaglutide only targets GLP-1
Uncertainty about long-term follow-up
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