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You may be ready to stop or down-titrate if: Cycles are regular (2635 days) Ovulation is consistent Luteal phase is stable (1014 days) Weight loss is ~510% Metabolic markers have improved At this point, the primary fertility benefit of GLP-1s has likely been achieved

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What does exist is a set of independent Phase 3 trials at matched endpoints, which is the basis for the comparison below

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In in-vitro and preclinical studies, it demonstrates notable effects on weight and glycemic indices, prompting further investigation into triple agonists that target GLP1, GIP, and glucagon receptors

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