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It also increases the production of stem cells and supports bone repair, suggesting systemic regenerative activity beyond dermatological applications

To put that in perspective: if your therapeutic dose is 500 mcg, you'd theoretically need 500,000 mcg (500 mg) to approach potentially toxic levels

10.1016/S0047-6374(01)00385-2 92 FormanH

It modulates neurotransmitter levels such as gamma-aminobutyric acid (GABA) and serotonin, which are critical in inducing and maintaining sleep over an extended period

Aerobic eukaryotes have developed antioxidant defense mechanisms which act by mitigating damaging effects of excessive ROS production, hence under physiological conditions there is a dynamic balance between the ROS generation and elimination [22]

Biochem Pharmacol 56: 13051313