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Safety Information About GLP-1 Class Drugs Final Notes Effectiveness of GLP-1 Medications on Weight Loss In clinical trials, GLP-1s drove 5-10% weight loss

Early experiments involving lesions in the hypothalamus demonstrated that the lateral hypothalamic area (LHA) is responsible for transmitting orexigenic signals (desire for food intake) and loss of this region results in starvation

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Importantly, GLP-1RAs are able to improve -cell sensitivity to glucose and have the ability to improve the glycaemic profile indirectly by delaying gastric emptying, inhibiting hepatic glucose production and suppressing appetite, thereby promoting weight loss [9,10,11]