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Sun exposure: Overexposure to UV rays can cause sunburns on depigmented skin areas, leading to an increased contrast between affected and unaffected skin and potentially worsening the condition

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In the present state of knowledge, it is believed that the pathogenesis of migraine, in all its complexity, is determined by, among others, genetic and epigenetic factors as well as the effect of numerous environmental factors [43]

Critically, advanced imaging showed that visceral fat volume decreased by approximately 25% in the tirzepatide group, while inflammatory markers like high-sensitivity C-reactive protein dropped by 30% to 40%